Immunoprevention of Friend Leukaemia Virus-induced Erythroleukaemia by Vaccination with Aggregated gp70
نویسندگان
چکیده
منابع مشابه
Suppression of Friend virus-induced leukaemia in mice by tuftsin.
A significant decrease in mortality was observed when 25 micrograms of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukaemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 microgra...
متن کاملNew cell surface gp70 related to Friend mink cell focus-inducing virus is expressed on Friend virus-induced erythroleukemic spleen cells after elimination of ecotropic Friend virus gp70 in Rfv-3r/s mice
Spleen cells from Rfv-3r/s mice with Friend virus-induced erythroleukemia were analyzed for expression of virus-induced proteins with monoclonal antiviral antibodies and conventional antisera. Leukemic spleen cells, 30-60 d after virus inoculation, expressed decreased amounts of ecotropic Friend murine leukemia helper virus gag- and env-encoded cell surface and intracellular proteins compared w...
متن کاملChronic lymphatic leukaemia terminating as erythroleukaemia.
Case report A 67-year-old man presented in May 1978 with malaise and splenomegaly. Initial blood count showed haemoglobin 12-1 g/dl, total white cell count 25 7 x 10'/1 (polymorphs 5 %, lymphocytes 93 %, eosinophils 2 %), platelet count 98 x 10'/1. Bone marrow examination showed a 66% infiltration by mature lymphocytes. Haematopoiesis otherwise was morphologically normal. A diagnosis of chronic...
متن کاملThe Friend leukaemia virus and Etienne de Harven - EPE
In 1957 Charlotte Friend was able to transmit, in mice, “a disease having the characteristics of leukaemia” by using cell-free filtrates obtained from the spleen of leukaemic mice. (Friend, J. Exp. Med. 1957; 105:307). In 1958 de Harven and Friend reported the finding in the filtrates of “virus-like” particles. “Particles were found in about one-quarter of the examined specimens from leukaemic ...
متن کاملFormation of Cytoxic Antibody against Leukemias Induced by Friend Virus.
A specific antigenic component in mouse leukemias induced by Friend virus has been demonstrated by cytotoxic tests in vitro. Serum from mice of several inbred strains immunized with histoincompatible Friend leukemia tissue contained antibody that was cytotoxic in vitro for leukemia cells induced by Friend virus in the strains providing the immune serum. Unexpectedly, a high proportion of mice f...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1986
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-67-9-1901